<p>The aim of this paper is to present current and emerging clinical and scientific evidence for the prevention of pressure ulcers in highly dependent aged care residents. The authors discuss recent developments in the use of multilayer silicone foam dressings used prophylactically in both the acute and nursing home settings and explain this preventative approach in the light of our current understanding of the role of cell and tissue deformations in the pathogenesis of these wounds. The authors also discuss how certain dressings can reduce the exposure to tissue deformations resulting from the mechanical loads of pressure, friction and shear in these highly vulnerable individuals. </p>