<p>A collaborative, multidisciplinary and long-term treatment approach, with the implementation of an effective therapy and management regimen, based on an agreed treatment pathway and goals, can bring about significant health and psychological benefits for those with obesity-related chronic oedema. Aim: To illustrate the role of compression bandaging as part of decongestive lymphatic therapy (phase I) and layering of custom-fit, flat-knit, RAL compression garments in the maintenance phase (phase II), can have positive treatment outcomes, as well as improvement patient mobility and quality of life. Method: Daily, bilateral, toe-to-thigh, short-stretch bandaging over a 3-week period followed by layering of custom-fit, flat-knit, RAL compression garments. Results: A 36% limb volume reduction (average of both limbs) was achieved in the presented case. Within 8 weeks of therapy commencement, ulceration and lymphorrhoea resolved. Conclusion: A long-term treatment approach, along with continued patient support, can provide positive treatment outcomes and tangible benefits to the patient’s quality of life.</p>