Quick Guide: Continuous Topical Oxygen Therapy (cTOT) for improved healing

15 April 2024

The challenge

  • 97% of chronic, non-healing wounds have low oxygen levels or chronic lack of oxygen (hypoxia)
  • Additional associated comorbidities will only compromise oxygen supply further 
  • Chronic hypoxia leads to inactivation of growth factors and cellular senescence, with eventual wound deterioration.

The solution

  • Oxygen is essential for wound healing, is required to create energy for cells to function and is essential for immune cells to attack bacteria, thus is pivotal in the host response to tackling infection2,3
  • Early intervention with supplemental oxygen to injured tissues, such as topical oxygen therapy (TOT), can help to correct this.

Introducing NATROX® O2

NATROX® O2 is a wearable medical device designed to deliver continuous topical oxygen therapy (cTOT) directly to a wound to support improved healing. 

Patients can continue with their normal daily activities as the device is:

  • Battery powered/portable
  • Discreet and completely silent
  • Easy to manage
  • Practical for everyday use.

NATROX® O2 is an adjunct to standard of care (SoC), providing oxygen to a wide range of chronic wounds, including:

  • Diabetic foot ulcers (DFUs)
  • Leg ulcers 
  • Pressure injuries
  • Open surgical wounds.

NATROX® O has also been shown to help relieve pain in hard-to-heal leg ulcers, whilst improving healing rates. In a recent study, 76% of patients reported substantial pain relief, which led to 69% discontinuing opioids.

Read to full Quick Guide below

Disclaimer: This Quick Guide was supported by an educational grant from NATROX® Wound Care, a brand of Inotec AMD Ltd
References

Hauser CJ (1987) Arch Surg 122(10): 1128–30

Frykberg R et al (2023) J Wound Care 32(Sup8b): S1–S32

Chen P et al (2023) Diabetes Metab Res Rev: e3644

Jebril W et al (2022) J Wound Care 31(1): 4–11

Yu J et al (2016) Wound Repair Regen 24(6): 1066–72

Gonçalves V, Schofield A (2024) Continuous Topical Oxygen Therapy Made Easy. Wounds International

Lavery LA et al (2023) Wound Repair Regen. doi:10.1111/wrr.13133.

ElSayed NA et al (2023) Diabetes Care 46(Suppl 1): S203–S215

ElSayed NA et al (2024) Diabetes Care 47 (Suppl 1): S231-S243

Carter MJ et al (2023) Adv Wound Care (New Rochelle) 12(4): 177–86

Sethi A et al (2022) Health Sciences Review 3: 100028

Sun XK et al (2022) Int Wound J 19(8): 2200–09

Thanigaimani S et al (2021) Diabet Med 38(8): e14585

Connaghan F et al (2021) J Wound Care 30(10): 823–29

Serena TE et al (2021) J Wound Care 30(Sup5): S7-S14

Al-Jalodi O et al (2022) Int Wound J 19(7): 1838–42

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