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Dialkylcarbamoyl Chloride-coated wound dressing: An Evidence Review and Position Document

Valerie Edwards-Jones, Patricia J Idensohn, Sam Westgate, Mark G Rippon, Alan A Rogers, John Stephenson, Joshua P Totty
17 September 2025

The prevention, treatment and management of wound infection consistent with antimicrobial stewardship is a global concern and yet one of the greatest obstacles for clinicians, considering wound infection severely impacts patient outcomes, clinical practices and financial costs. The lack of clinical evidence with high certainty, of the plethora of topical antimicrobial dressings available for the clinicians appropriate selection adds to the challenge of wound infection management, when evidenced based practice is the practitioner’s foundation in healthcare. 

Antimicrobial resistance (AMR) which occurs when bacteria, viruses, fungi and parasites no longer respond to antimicrobial medicines is a growing healthcare concern. The World Health Organisation (WHO) has identified AMR as being one of the top global public health and development threats. Wound infections caused by antimicrobial resistant pathogens pose a considerable challenge to treatment, increasing complexity, time requirements, and costs while also limiting available therapeutic options.

The search for new antimicrobial agents has expanded beyond traditional antibiotics, whose development has been scarce over the past two decades, to include innovative technologies such as photodynamic therapy, phage therapy, and advanced wound dressings that use physical antimicrobial mechanisms. Among these, DACC (Dialkylcarbamoyl Chloride) -coated wound dressings have demonstrated significant anti-infective efficacy in both laboratory and clinical studies. 

A group of experts from the United Kingdom, Europe and South Africa identified the need for an evidenced review to provide internationally recognised guidance for the use of DACC dressings, based on the available evidence.

A narrative review of the literature is presented in each chapter of this position document presenting and critically examining the published in vitro and clinical evidence surrounding the antimicrobial capabilities of DACC-coated wound dressings and how DACC can be aligned with AMS in the prevention, treatment and management of infection to enable wound healing, in acute, chronic and hard to heal wounds.

Patricia J Idensohn

Mark G Rippon

Download the PDF below to access the full position document

Disclaimer: This document has been developed by Wounds International and supported by Essity.
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