Al-Jalodi O, Kupcella M, Breisinger K et al (2022) A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1 year post healing. Int Wound J 19(7): 1838–42
Al Sadoun H (2022) Macrophage phenotypes in normal and diabetic wound healing and therapeutic interventions. Cells 11(15): 2430
Allen DB, Maguire JJ, Mahdavian M et al (1997) Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch Surg. 132(9): 991–6
Asmis R, Qiao M, Zhao Q (2010) Low flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and reepithelialization. Int Wound J. 7(5): 349–57
Boersema GC, Smart H, Giaquinto-Cilliers MCG et al (2021) Management of nonhealable and maintenance wounds: a systematic integrative review and referral pathway. ASWC 34: 11–22
Carter M, Frykberg RG, Oropallo A et al (2022) Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis. Adv Wound Care 12(4): 177–86
Chen P, Campillo Vilorio N, Dhatariya K et al (2023) Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev 40(3): e3644
Cole W, Woodmansey E (2025) Monitoring the effect of continuous topical oxygen therapy with near-infrared spectroscopy: a pilot case series in wound healing. Wounds. 37(2): A4. doi: 10.25270/wnds/0225-03. Erratum for: Wounds. 2024 May;36(5): 154–59
Connaghan F, Avsar P, Patton D et al (2021) Impact of topical oxygen therapy on diabetic foot ulcer healing rates: a systematic review. J Wound Care 30(10): 823–29
Dawi J, Tumanyan K, Tomas K et al (2025) Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies. Biomedicines. 13(5): 1076
Du X, Zhang X, Liu J et al. (2024) Effects of oxygen therapy
on patients with a chronic wound: a systematic review and meta-analysis. Adv Skin Wound Care, 37(5): 1–9
ElSayed NA, Aleppo G, Aroda VR et al; American Diabetes Association (2023) 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes—2023. Diabetes Care 46(Suppl 1): 203–15
ElSayed NA, Aleppo G, Bannuru RR et al; American Diabetes Association Professional Practice Committee (2024) 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes—2024. Diabetes Care 47(Suppl 1): 231–43
Fraisl P, Mazzone M, Schmidt T, Carmeliet P (2009) Regulation of angiogenesis by oxygen and metabolism. Dev Cell 16(2): 167–79
Frykberg RG, Franks PJ, Edmonds M et al; TWO2 Study Group (2020) A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 Study. Diabetes Care 43: 616–24
Frykberg R, Andersen C, Chadwick P et al (2023) Use of topical oxygen therapy in wound healing. J Wound Care 32, S1–S32
Goldberg MA, Schneider TJ (1994) Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269(6): 4355–59
Handelsman Y, Butler J, Bakris GL et al (2023) Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases. J Diabetes Complic 37(2): 108389
Heffner JE (2012) The story of oxygen. Respir Care 58(1): 18–31
Knighton DR, Silver IA, Hunt TK (1981) Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery 90: 262–70
Lavery LA, Suludere MA, Attinger CE et al (2024) WHS (Wound Healing Society) guidelines update: diabetic foot ulcer treatment guidelines. Wound Repair Regen 32(1): 34–46
Lee CC, Wu CY, Yang HY (2020) Discoveries of how cells sense oxygen win the 2019 Nobel Prize in Physiology or medicine. Biomed J 43(5): 434–37
Martinengo L, Olsson M, Bajpai R et al (2019) Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies. Ann Epidemiol 29: 8–15
Miller DP, Levere TH (2008) “Inhale it and see?” The collaboration between Thomas Beddoes and James Watt in pneumatic medicine. Ambix 55(1): 5–28
Miyasaka K, Shelley K, Takahashi S et al (2021) Tribute to Dr. Takuo Aoyagi, inventor of pulse oximetry. J Anesth 35(5): 671–709
Monika P, Chandraprabha MN, Rangarajan A et al (2022) Challenges in healing wound: role of complementary and alternative medicine. Front Nutr 8: 791899
OuYang H, Yang J, Wan H et al (2024) Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis. Front. Endocrinol 15: 1452192
Ramirez H, Patel SB, Pastar I (2014) The Role of TGFβ Signaling in Wound Epithelialization. Adv Wound Care (New Rochelle) 3(7): 482–91
Rodrigues M, Kosaric N, Bonham CA, Gurtner GC (2018) Wound healing: a cellular perspective. Physiol Rev 99(1): 665–706
Sen CK (2009) Wound healing essentials: Let there be oxygen. Wound Repair Regen 17(1): 1–18
Serena TE, Bullock NM, Cole W et al (2021) Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled trial. J Wound Care, 30(Suppl 5): 7–14
Sun XK, Li R, Yang XL et al. (2022) Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: an updated systematic review and meta-analysis. Int Wound J 19(8): 2200–9
Yu J, Lu S, McLaren AM et al (2016) Topical oxygen therapy results in complete wound healing in diabetic foot ulcers. Wound Repair Regen 24: 1066–72
Free for all healthcare professionals
By clicking ‘Subscribe’, you are agreeing that the Wounds Group are able to email you periodic newsletters. You may unsubscribe from these at any time. Your info is safe with us and we will never sell or trade your details. For information please review our privacy policy.
Are you a healthcare professional? This website is for healthcare professionals only. To continue, please confirm that you are a healthcare professional below.
We use cookies responsibly to ensure that we give you the best experience on our website. If you continue without changing your browser settings, we’ll assume that you are happy to receive all cookies on this website. Read about how we use cookies.