Diabetes is related to numerous comorbidities, including the severe complications of poor wound healing, often resulting in chronic ulceration and consequent limb amputation. In wound healing, diabetes leads to improper function at all stages, with severe impairment of the vascular network. Photobiomodulation positively influences tissue regeneration and healing, modulating the inflammatory response and promoting angiogenesis. This case series evaluated the effect of blue light treatment (EmoLED) on 11 patients with diabetes with recalcitrant ulcers of various aetiology that were not responding to standard therapies. Results show that blue light therapy provides a positive contribution to standard treatments for wound healing in patients with diabetes, significantly improving reepithelisation and allowing complete recovery of chronic ulcers in most cases.