<p>Diabetic foot ulcers and associated wound care methodologies have been the subject of rigorous research during the last decade. It is important for clinicians to educate themselves on the latest therapies and incorporate them into wound care protocols appropriately. This report reviews innovations in diabetic foot care from a US perspective and provides a guide to the effective use of advanced therapies, including debridement, promotion of granulation tissue and wound closure, to help clinicians achieve optimum wound healing.</p>