<p>Background: Women with breast cancer-related lymphoedema (LE) can experience physical, psychological, and sexual problems as a result of both physical limitations and appearance associated with this condition. Aims: This study investigated the effect on quality of life of the sexual relationships with intimate partners for women with LE. Methods: Participants were 11 women with LE. Qualitative in-depth interviews were used to elicit participants’ descriptions of quality of life with breast cancer-related LE, and in what ways breast cancer-related LE has impacted on their sexual relationships. A cooperative, inductive approach to data analysis was used. Results: These findings show that breast cancer-related LE has an important and often negative influence on women’s experiences of sexuality and intimacy and demonstrates how sexuality includes multiple domains of influence, including feelings about self as well as relationships. Conclusions: Family life educators and healthcare professionals should use these findings to assist women with breast cancer-related LE in their intimate relationships following diagnosis. Declaration of interest: None.</p>