People living with chronic wounds face substantial challenges to their wellbeing, including stigma, psychological stress, malodour, treatment regimens and social isolation. This is significant, since increased wellbeing is associated with faster wound healing and better mental health. Considerable research has highlighted the impact of personality on general health and there is emerging evidence that personality (particularly the trait ‘neuroticism’) can have considerable influence on the wellbeing of someone living with a chronic wound. Consequently, the authors recommend that treatment plans consider personality, since this has the potential to facilitate new interventions to improve wellbeing that are more tailored to an individual’s needs.