To gain knowledge and have a high quality of practical skills in wound care is a challenge. The experience in clinical practice is that the basic nurses have a lack of self-confidence when performing wound care, as well as a lack of skills. These challenges have grown bigger over a number of years, and action is needed. To deal with the challenges, Odense University Hospital, Denmark, has developed a blended learning concept in wound care. The concept contains an e-learning module combined with a 2-day study visit in a department of wound healing. A third part of blended learning is four to six meetings with different themes. The meetings contain workshops and walk through different cases. This paper aims to present an overview of the wound care challenges in clinical practice, as well as possible solutions to those challenges.