The authors present nine cases of patients affected by atypical refractory ulcers due to different factors, including origin, chronicity, general medical conditions or localisation. The patients were treated with recombinant human collagen. After a week, superficialisation of the lesion occurred in all patients and, in a month, the wounds healed in three patients. A reduction in size of more 50% was observed in five patients with larger wounds. The patient suffering from necrotic angiodermatitis died as a result of severe renal insufficiency. Appreciable pain reduction was experienced by all the patients and an appreciable improvement in perilesional skin trophism was observed. No allergy or adverse event was observed in any patient.
