The study focuses on the cost-effectiveness analysis of wound treatment with cyanoacrylate topical adhesive, skin glue. A descriptive, exploratory, cross-sectional study with a convenience sample was used to analyse the effectiveness and annual direct cost of using N-butyl-2-cyanoacrylate topical adhesive in simple wounds in primary health care units in the Algarve region of Portugal. These results were compared to the use of surgical sutures for the same type of wounds. Wound care studies are important for a number of reasons, including improving the quality of care, as well as for patient safety, accessibility and equity of access to healthcare and resource management.