In 2016, the International Wound Infection Institute reviewed the wound infection continuum through a literature review and formal Delphi process. This article discusses some significant changes made to the wound infection continuum, including changes in terminology used to describe phases of wound infection, and distinction between early (covert) signs of local infection and the overt classic Celsian signs. Clinical indicators of potential biofilm in a wound, which were agreed on by experts as part of the Delphi process, are explored. An overview of strategies to manage local wound infection, and the important role of antiseptics in providing an option for early action against microbial proliferation, are also presented.