Oxygen is needed in every phase of wound healing; however, chronic wounds are often hypoxic. Topical oxygen therapy (TOT) is an intervention that can be used to improve oxygen saturation in the wound bed and support healing, especially in the management of hard-to-heal wounds, such as diabetic foot ulcers, venous leg ulcers and pressure ulcers. One approach to providing TOT to wounds is through the application of Granulox®, a topical haemoglobin spray (Mölnlycke, Sweden), as an adjunctive therapy. In numerous clinical studies, it has been demonstrated that the inclusion of Granulox as part of the standard of care for hard-to-heal wounds can accelerate their healing and impart associated economic benefits. A Mölnlycke-sponsored symposium was held at the European Wound Management Association 2022 Conference in Paris, France. The symposium covered three main areas: introduction to the concept of TOT and the use of Granulox, clinical experience in the form of case studies using Granulox as an adjunctive therapy, including those from a revascularisation perspective and, finally, the health economic perspective of using Granulox as an adjunctive therapy.