The Infection Management (IM) Pathway is a comprehensive, succinct, expert-endorsed, evidence-based pathway that can assist clinicians in the diagnosis and management of infection (Dowsett et al, 2020). This article describes the real-world experiences of a clinical team who have implemented the IM pathway into daily practice. They have formally evaluated three clinical cases. The IM pathway helped to guide diagnosis of infection, wound bed preparation, treatment and ongoing management of chronic wounds including the clarification of biofilm based wound care and management of local infection. The clinicians involved reported that the IM pathway was easy-to-follow and they felt more confident managing infected wounds with the support of the IM pathway.