Oncology patients have a higher risk of developing wound complications associated with procedures and agents used for cancer treatment. This observational case series investigated the clinical benefits of a silver alginate paste dressing in the management of stalled or deteriorating non-malignant wounds showing clinical signs of local infection or considered at high risk of infection in cancer patients. Fifteen patients were managed using the same standard wound care protocol. Wounds were associated with complications of cancer treatment, such as surgery (surgical site complications) or radiotherapy (chronic radiation dermatitis). Data were collected at inclusion and at the end of week 1, 2, and 4. During follow-up, six wounds healed, two improved, four showed small improvements and three wounds did not change or deteriorated. The silver alginate paste showed efficacy to control clinical signs of infection from the first week. A careful and individualised use of this silver alginate paste in stalled or deteriorating wounds showing signs of local infection can help promote healing.