Dyshidrosis is a chronic dermatitis accounting for approximately 5% to 20% of all hand dermatitis. Treatment often includes several options, most commonly topical steroids and other medications. Eosin is a staining agent used in several skin diseases, such as psoriasis, and due to its safety, it has been associated with positive outcomes as a substitute to more aggressive topical medications. This case report describes a successful result of hand dyshidrosis in a young man treated with topical eosin 2% only, as an alternative option to topical steroids where a complete skin recovery was achieved after a 2-week treatment window.