<p>Collagen-containing dressings have a broad evidence base for efficacious use; collagen/oxidised regenerated cellulose (ORC) in particular restores balance to the wound’s microenvironment, which is critical to healing. Clinicians should consider collagen/ORC dressings when faced with a stalled wound, or where healing may be complicated by risk factors. In three case studies detailed herein, holistic assessment was undertaken to determine risk and choose a course of management that included a collagen/ORC dressing and other therapies as appropriate. In each case, despite long periods of non-healing and the presence of complicating factors, collagen/ORC dressings restarted healing and led to full wound closure. These outcomes demonstrate collagen/ORC is a cost-effective choice when implemented appropriately. </p>